Here's the movie plot summary: In the midst of an international crisis, a sudden and mysterious murder takes place in a White House bathroom. The victim is found to be a secretary working for the First Lady, and the President himself becomes entangled in the case when he receives an anonymous threat claiming responsibility for the crime. As tensions rise, Detective Harlan Regis, a no-nonsense and sharp-witted investigator from the DC Police Department, is called in to lead the investigation. Despite resistance from the Secret Service, who are hesitant to allow an outsider to meddle with their internal affairs, Regis proves his worth by uncovering clues that point to a sinister plot involving high-ranking officials. As the investigation unfolds, Regis discovers that the murder may be linked to a series of cryptic messages and mysterious events taking place around Washington D.C. With the help of his trusted partner, Detective Bobbi Clearwater, Regis must navigate the treacherous waters of White House politics and bureaucratic red tape to uncover the truth behind the murder. As the stakes grow higher, Regis finds himself at odds with both the Secret Service and other powerful figures who will stop at nothing to keep their secrets hidden. With his reputation on the line and the nation's trust hanging in the balance, Regis must use all his wits and expertise to solve the case before it's too late. Murder at 1600 is a gripping thriller that combines political intrigue, suspense, and wit, as Detective Harlan Regis takes on the challenge of a lifetime: solving a murder in the most secure building in the country.